Abstract

Recent advances in implantable medical devices demand seamless, efficient, and miniaturized solutions for organ-specific wireless communication and power transfer. The integration of antenna systems into bioelectronics offers a transformative path to realizing robust biotelemetry and energy harvesting capabilities. Traditional antenna designs are hindered by biological loading effects, size constraints, and inconsistent power transfer across varying tissue types. This work presents a novel Integrated Antenna System (IAS) tailored for miniaturized organ-specific bioelectronics, designed to operate efficiently within heterogeneous tissue environments. The proposed system combines metamaterial-inspired miniaturization with substrate- integrated antennas, optimized through electromagnetic simulations to support dual functionality: robust biotelemetry and wireless power transfer (WPT). A multi-band design approach is employed to ensure compatibility with Medical Implant Communication Service (MICS) and Industrial, Scientific, and Medical (ISM) bands, crucial for real- time data transfer and sustained operation. Extensive simulations using CST Microwave Studio and HFSS validate the electromagnetic behavior within heterogeneous anatomical models (brain, heart, and liver tissues). Results indicate enhanced power transfer efficiency (> 65%) and stable radiation performance with minimal tissue heating (SAR < 1.6 W/kg). In-vitro and in-vivo prototypes show consistent impedance matching and link reliability, with telemetry range exceeding 10 cm and power transfer above 5 mW, sufficient for organ- specific bioelectronic function.